Figure 1.

SFN induces growth inhibition and cell death in SCLC cells. (A) H69 cells were treated with 0, 1, 5, 10 and 20 µM SFN for 0, 24, 48 and 96 h then, cell viability was determined using a MTT assay. (B) The H69 and H69AR SCLC and 16HBE cell lines were treated with 20 µM SFN for 96 h then, cell death was determined using a lactate dehydrogenase assay. (C) Representative images of H69 cells in the presence or absence of SFN (20 µM, 96 h) treatment. Magnification, ×20. Data are presented as the mean ± SD (n≥3). *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001. SFN, sulforaphane; SCLC, small cell lung cancer; N.S., not significant.