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. 2020 Nov 25;21(1):71. doi: 10.3892/ol.2020.12332

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Copyright: © Iida et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — An overview of the SFN-induced ferroptosis pathway. SFN-induced ferroptosis observed in small cell lung cancer cells is triggered by the inhibition of SLC7A11, resulting in decreased intracellular levels of Cys and GSH. This effect leads to the accumulation of iron-dependent lipid ROS. Ferroptosis is inhibited by ferrostatin-1 and DFO. SFN, sulforaphane; SLC7A11, cystine/glutamate antiporter xCT; Cys, cysteine; GSH, glutathione; ROS, reactive oxygen species; DFO, deferoxamine; Glu, glutamate; TFR: transferrin receptor; GPX4, glutathione peroxidase4.