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. 2020 Dec 4;22:100979. doi: 10.1016/j.genrep.2020.100979

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Fig. 3 — Prediction of biological pathways and function of ACE2 by KEGG. The renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics involved in the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the renin enzyme cleaves its substrate angiotensinogen (AGT) forming the decapeptide angiotensin I that is in turn cleaved by angiotensin-converting enzyme (ACE) to produce the angiotensin II, a key player of this system. In addition to (ACE)/angiotensin II/AT1R and AT2R axis, other signaling pathways in the RAS, such as ACE2/angiotensin-(1–7)/MAS and angiotensin IV/insulin-regulated aminopeptidase (IRAP), and other active peptides of the RAS, with physiological relevance as angiotensin III, angiotensin A and alamandine, are now widely recognized. AGT; angiotensinogen; REN: renin; ACE2: angiotensin-converting enzyme 2; CTSA: cathepsin A; CPA3: carboxypeptidase A3; THOP1: thimet oligopeptidase 1; NLN: neurolysin; MME: membrane metallo-endopeptidase; CMA1: chymase 1, mast cell; CTSG: cathepsin G; PRCP: prolylcarboxipeptidase; AngA: angiotensin A; MAS1: MAS1 oncogene; MRGPRD: MAS Related GPR Family Member D; ATR2: ATR Serine/Threonine Kinase.