Table 2.
Summary of the cellular functions of miRNAs in tumorigenesis of TNBC.
| LncRNAs | Role in TNBC | Mechanism | Biological function in TNBC | References |
|---|---|---|---|---|
| HOTAIR | oncogenic | Remodeling chromatine, modulate PRC2 | poor survival rates, marker of metastasis, chemoresistance |
(83–93) |
| MALAT1 | oncogenic | PI3k/AKT/mTOR and Wnt/β-catenin pathways sponge for miR-129-5p |
proliferation, progression, metastasis | (94–98) |
| HULC | oncogenic | Regulation ofMMP-2 and MMP-9 | Correlation with stage and overall survival | (99, 100) |
| AWPPH | oncogenic | upregulation of FZD7 association with miR-21 |
Correlate with tumor size, Involved in chemoresistance |
(101, 102) |
| ARNILA | oncogenic | Enhances SOX4, induce EMT | Migration, metastasis | (103) |
| SNHG12 | oncogenic | Regulation of MMP13 expression | Correlated with lymph node involvement, metastasis | (104) |
| H19 | oncogenic | Inhibits BIK and NOXA (Bcl2 family) and reduces apoptosis | poor prognosis, chemo-resistance |
(105) |
| POU3F3 | Tumor suppressor | Regulates Caspase-9 | promotes proliferation and inhibits apoptosis | (106) |
| RMST | Tumor suppressor | regulation of mRNA/proteins | prevent migration and invasion | (107) |
| NEF | Tumor suppressor | downregulates miR-155 | increased migration and invasion | (108) |
| Airn | Tumor suppressor | suppresses the Wnt/β-catenin/mTOR/PI3K pathway | Increase migration and invasion | (109) |
PRC2, Polycomb Repressive Complex 2; MMP, matrix metalloproteinase.