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. 2020 Oct 7;64(1):119–128. doi: 10.1007/s00125-020-05287-1

Table 3.

HR (95% CI) from univariate and multivariate Cox time to the development type 1 diabetes model

Variable Univariate models Multivariate model
HR (95% CI) p value HR (95% CI) p value
Family history from mother 0.43 (0.29, 0.65) <0.001 0.58 (0.36, 0.93) 0.023
Family history from father 0.62 (0.41, 0.93) 0.021 0.67 (0.41, 1.09) 0.104
HLA risk 1a 2.35 (1.71, 3.24) <0.001 2.21 (1.54, 3.16) <0.001
Height velocity (z score) 1.38 (1.07, 1.78) 0.012 1.41 (1.10, 1.82) 0.007
Birth length 1.01 (0.95, 1.07) 0.732
Weight velocity, z score 1.40 (1.06, 1.84) 0.017
Male sex 1.07 (0.78, 1.46) 0.682
Birthweight 0.99 (0.74, 1.31) 0.930
Gestational age, weeks 1.03 (0.94, 1.14) 0.539
Region of origin
 Northern Europe 1.09 (0.77, 1.56) 0.625
 Central Europe 1.02 (0.62, 1.67) 0.936
Vaginal delivery 1.28 (0.93, 1.77) 0.132
Treatment group assignment, casein hydrosylate formula 1.06 (0.78, 1.45) 0.717
Exclusive breastfeeding duration 1.05 (0.98, 1.13) 0.183
Birth order 1.08 (0.93, 1.25) 0.307

aHLA-DQB1*02/DQB1*03:02