Supplementary Table 1.

Risk of bias assessment for using Cochrane collaborative tool

Study	Random sequence generation	Allocation concealment	Blinding of participants and personnel	Blinded outcome assessment	Incomplete outcome data	Selective reporting	Other bias	Overall risk of bias
ARO-96-02	Low	Low	High	High	Low	Low	Low	Low
EORTC 22911	Low	Low	High	High	Low	Low	Moderate	Moderate
SWOG 8794	Low	Low	High	High	Low	Low	High	High
FP-FINROG-0301	Low	Low	High	High	Low	Low	Low	Low