Table 1.

Trial part 1: adjusted geometric means (Adj. gMean), geometric mean ratios, and 90% confidence intervals (CIs) for the primary pharmacokinetic parameters of digoxin, furosemide, metformin, and rosuvastatin administered as a cocktail with and without the inhibitor rifampin

Endpoint	Test (T)		Reference (R)		Ratio T/R	90% CI	gCVa
	Cocktail + rifampin		Cocktail alone
	N	Adj. gMean	N	Adj. gMean	%	%	%
Digoxin
AUC0–tz (nmol·h/L)	12	17.89	12	13.61	131.41	115.93–148.97	17.9
Cmax (nmol/L)	12	2.55	12	1.17	218.26	180.19–264.36	27.7
Furosemide
AUC0–tz (nmol·h/L)	12	211.82	12	176.85	119.78	110.03–130.39	12.1
Cmax (nmol/L)	12	119.66	12	88.59	135.07	117.83–154.84	19.6
Metformin
AUC0–tz (nmol·h/L)	12	1473.38	12	1357.34	108.55	100.68–117.03	10.7
Cmax (nmol/L)	12	251.32	12	223.78	112.31	102.26–123.35	13.4
Rosuvastatin
AUC0–tz (nmol·h/L)	12	303.81	12	87.29	348.06	299.64–404.31	21.5
Cmax (nmol/L)	12	77.00	12	6.84	1125.10	914.63–1384.00	30.1

AUC_0–tz area under the plasma concentration–time curve up to the last quantifiable concentration, C_max maximum plasma concentration, gCV geometric coefficient of variation

^aWithin-subject gCV