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. 2020 Dec 1;115(6):76. doi: 10.1007/s00395-020-00837-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Leaflet TNC expression in the ischemic MR animal models and patients’ samples. Tenascin C (TNC) staining (black arrows) of anterior (Ant) and posterior (Post) mitral leaflet. Scale bar 100 µm (a) Quantitative analyses of TNC staining and its correlation to leaflet thickness; *p < 0.01, **p < 0.001 (b). TNC staining (black arrows) was mostly present in the atrial side of the posterior mitral leaflet in the pigs (upper panel) and in the sheep (lower panel); (c) representative TNC staining of mitral leaflet from human patient with ischemic MR (d)