Table 3.

Glucodynamics of ultra rapid lispro (URLi) and Humalog in patients who completed both treatment periods

Parameter	Treatment	N	Geometric LSM	Difference in LSM URLi–Humalog (95% CI)	p value	Ratio of geometric LSM URLi:Humalog (95% CI)
Early insulin action
Tonseta, min	Humalog	37	44.99	− 12.89 (− 18.67 to − 7.12)	< 0.0001	0.71 (0.62–0.82)
	URLi	37	32.10
Early 50% tRmaxa, min	Humalog	36	55.94	− 2.16 (− 11.69 to 7.37)	0.6486	0.96 (0.80–1.14)
	URLi	36	53.78
Gtot,0–30mina, mg/kg	Humalog	37	2.82	9.14 (5.02 to 13.25)	< 0.0001	4.24 (2.46–11.15)
	URLi	37	11.96
Gtot,0–1ha, mg/kg	Humalog	37	41.95	31.39 (19.68 to 43.11)	< 0.0001	1.75 (1.42–2.33)
	URLi	37	73.35
Late insulin action
Duration of actiona, min	Humalog	37	404.90	− 18.38 (− 60.70 to 23.94)	0.3840	0.95 (0.86–1.06)
	URLi	37	386.52
Late 50% tRmaxa, min	Humalog	36	269.18	− 23.62 (− 58.64 to 11.40)	0.1795	0.91 (0.80–1.05)
	URLi	36	245.56
Gtot,4h–Enda, mg/kg	Humalog	37	286.44	− 55.90 (− 97.52 to − 14.27)	0.0099	0.80 (0.68–0.94)
	URLi	37	230.54
Total insulin actionBlevins T, Zhang Q, Frias JP, Jinnouchi H,
Rmax, mg/kg/min	Humalog	37	2.89	–	0.0008	1.27 (1.11–1.44)
	URLi	37	3.66
Gtot, mg/kg	Humalog	37	670.26	–	0.0575	1.12 (1.00–1.26)
	URLi	37	750.27

CI confidence interval, early 50% tR_max time to half-maximal glucose infusion rate before maximum glucose infusion rate, G_tot total amount of glucose infused over the duration of the clamp, G_tot,0–1h G_tot over 1 h, G_{tot,0–30min} G_tot over 30 min, G_tot,4h–End G_tot 4 h to end of clamp, late 50% tR_max time to half-maximal infusion rate after maximum glucose infusion rate, LSM least squares mean, R_max maximum glucose infusion rate, T_onset time to onset of insulin action, tR_max time to maximum glucose infusion rate

^ap value is for the treatment difference in LSM. For all other values, the p value is for the ratio of geometric LS mean