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. 2020 Aug 18;43(6):1161–1174. doi: 10.1007/s13402-020-00549-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Macrophage influx correlates with EMT of cancer cells. High CD68 and CD163 macrophage marker expression in stroma indicate enhanced EMT in epithelial cells. (A-B) Differential expression analysis of tumor cells dichotomized on the stromal expression of CD68 (A) or CD163 (B) with genes from the Hallmark_EMT signature highlighted in red. (C-D) Gene Set Enrichment Analysis (GSEA) results for human PDAC cells from the GSE93326 expression set (dichotomized for median CD68 (C) or CD163 (D)) with the Hallmark_EMT signature. Normalized Enhancement Score (NES) and Family-Wise Error Rate (FWER) p-values are shown on the enrichment plots