Fig. 2.
Effect of sirolimus (SIR) versus torin2 on cyst burden and kidney function in Pkd1RC/RC mice. A: 2-kidney weight-to-body weight ratio (2KW/BW) in wild-type (WT) versus Pkd1RC/RC (PKD) mice treated with vehicle (VEH), torin2, or sirolimus. B: blood urea nitrogen (BUN). C: serum creatinine. D: cystic index (percentage of cross-sectional area). E: cyst number (per cross-sectional area). Values are means ± SE; n = 4–5 per group. *P < 0.05 and #P < 0.0001 (by ANOVA with a Newman-Keuls post test). NS, not significant. F: representative hematoxylin and eosin-stained sections. Scale bar = 1 mm.