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. 2020 Mar 10;318(5):E689–E700. doi: 10.1152/ajpendo.00174.2019

Fig. 2.

Fig. 2.

Knockdown of Phd2 in macrophages leads to impaired glucose metabolism after 12 wk of high-fat diet (HFD). A: amount of food consumed by LysMcre control and Phd2flox/flox/LysMcre mice during HFD. B: body weight gain in LysMcre and Phd2flox/flox/LysMcre mice during 12 wk of HFD (n = 9–15 per group). C: fasting glucose levels in LysMcre and Phd2flox/flox/LysMcre mice after HFD (n = 9–15 per group). D: blood glucose response curves of LysMcre and Phd2flox/flox/LysMcre during intraperitoneal insulin tolerance test after HFD, and their corresponding area under the curve (AUC) on the right (n = 9–14 per group). E: blood glucose response curves of LysMcre and Phd2flox/flox/LysMcre during oral glucose tolerance test after HFD, with the corresponding AUC on the right (n = 9–15 per group). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.