Fig. 2.

Adult offspring administered low protein during the last week of gestation (LP12.5) exhibit glucose intolerance, but only females display insulin resistance. Intraperitoneal glucose tolerance tests were performed in 6- and 50-wk-old male [A and B, area under the curve (AUC), P = 0.026] and 6- and 48-wk-old female (C and D, AUC, P = 0.056) LP12.5 and control (Ctrl) offspring. Intraperitoneal insulin tolerance tests (ITT) were performed in 10- and 54-wk-old male (E and F, AUC, P = 0.787) and 8- and 51-wk-old female (G and H, AUC, P = 0.01) LP12.5 and Ctrl mice. *P < 0.05 vs. Ctrl. Analyzed by Student’s t test, 2 tailed and unpaired, *P < 0.05 vs. Ctrl, n = 4–9 animals in each group.