Table 2.
SUMO E3 ligases
| Name | Substrate | Function |
|---|---|---|
| PIAS1 | Foxp3 | Regulate Treg differentiation (116) |
| Sp3 | Silencing of Sp3 (160) | |
| PIAS3 | IRF-1 | Repress IRF-1 transcription activity (135) |
| PIASy | HIF1a | Increase HIF1α stability in hypoxia (90) |
| MMS21 | SMC6 | DNA repair (144) |
| RanBP2 | RanGAP1 | Nuclear transport (141) |
| HDAC4 | Modulate deacetylase activity (100) | |
| Pc2/CBX4 | CtBP1 | Polycomb body may be SUMOylation center (84) |
| Topors | p53 | Increase in p53 level (202) |
| MAPL | Drp1 | Regulate mitochondrial fission (20) |
| Rhes | Huntingtin | SUMOylated huntingtin is cytotoxic (179) |
| ZATT | Topoisomerase 2 | Resolution of the TOP2 cleavage complex (161) |
| KAP1 | IRF7 | Regulation of IRF7’s transactivation activity (30, 112) |
HIF1α, hypoxia-inducible factor 1α; SUMO, small ubiquitin-like modifier.