Table 3.
SUMO proteases
| Name | Isoform Preference | COOH-Terminal Hydrolase | Iso-peptidase | Chain Editing | Regulation |
|---|---|---|---|---|---|
| SENP1 | All SUMO | Yes | Yes | No | Hypoxia (210); androgen (8); IL-6 (31) |
| SENP2 | All SUMO | Yes | Yes | No | Ubiquitin-mediated degradation in the cytosol (79); phosphorylation (72) |
| SENP3 | SUMO2/3 | No | Yes | No | Ubiquitin-mediated degradation in the nucleolus (78); oxidative stress stabilizes SENP3 (78) |
| SENP5 | SUMO2/3 | Yes | Yes | No | Mitochondrial fission (227) |
| SENP6 | SUMO2/3 | No | Yes | Yes | Homologous recombination (40) |
| SENP7 | SUMO2/3 | No | Yes | Yes | SENP7L, SENP7S (9) |
| DeSI1 | All SUMO | No | Yes | Weak | Limited substrate, BZEL (167) |
| DeSI2 | ? | No | ? | ? | ? |
| USPL1 | SUMO2/3 | Weak | Yes | Yes | Regulation of coilin localization independent of enzyme activity (162) |
IL-6, interleukin-6; SENP, Sentrin-specific protease; SUMO, small ubiquitin-like modifier.