Table 4.

SENP, physiology, and disease association

	Physiology	Disease Association
SENP1	HIF1α stability in hypoxic condition (32); immune-mediated destruction of β cells (163); insulin secretion (44)	Cancer (7, 10); type I diabetes mellitus (163); type II diabetes mellitus (44)
SENP2	Regulate Kv7.2/Kv7.3 channels (148); p90RSK mediated phosphorylation of SENP2 (72); regulate SUMOylation of Setdb1 (225)	Sudden unexplained death in epilepsy (148); atherosclerosis (72); adipocyte lipid storage (225)
SENP3	Regulate p300 interaction with HIF1α (78); regulate Top2α (203); regulate BACH2 SUMOylation (219)	Cancer (151); genomic instability (203); Treg stability and function (219)
SENP5	Regulate mitochondrial fission through Drp1 (227)	Cardiomyopathy (95)
SENP6	Regulate RPA70 SUMOylation (40); regulate osteochondroprogenitors (108)	Cancer (40); premature aging (108)
SENP7	Endothelial mesenchymal transition (9)	Breast cancer (9)

HIF1α, hypoxia-inducible factor 1α; SENP, Sentrin-specific protease; SUMO, small ubiquitin-like modifier.