Fig. 6.

The tremor phenotype is stronger in Global-KO than in PC-KO animals. A: summary tremor band ratio (TBR) data for PC-KO-Bl6 animals (gray column), PC-KO-Mixed animals (blue), and Global-KO animals (red). While PC-KO-Bl6 and PC-KO-Mixed animals showed similar TBR values, Global-KO animals showed greater levels of tremor (P < 0.0001), as measured by the TBR. Individual animal data points are also presented by sex: triangles represent male animals; diamonds represent female animals. Note that many data points are overlapping. Light gray bars represent averages by sex within each group. B–F: Global-KO animals also showed a more severe tremor phenotype (P < 0.0001) as assessed by average tremor bout rate (B), bout amplitude (C), and bout length (D). Cumulative histograms of individual bout amplitudes (E) and length (F) by strain. HEMI, hemizygous; KO, knockout; PC, Purkinje cell; WT, wild-type.