Table 1.

Properties of Purkinje cell and molecular layer interneuron IPSCs

Genotype	Frequency, Hz			Amplitude, pA			Decay Tau, ms			no. of cells
PC-BL6: Purkinje Cells
WT	13.5 ± 1.4	Kruskal–Wallis	P = 0.00012	80.4 ± 23.3	MW WT vs. HEMI		13.5 ± 1.5	MW WT vs. HEMI	P = 0.18	13
HEMI	14.8 ± 2.1	MW WT vs. HEMI	P = 0.64	44.0 ± 6.1		P = 0.15	10.5 ± 2.6			6
KO	0.01 ± 0.01	MW KO vs. WT	P = 0.000004							9
		MW KO vs. HEMI	P = 0.0004
PC-BL6: Molecular Layer Interneurons
WT	21.9 ± 2.6	MW WT vs. KO	P = 0.19	46.6 ± 4.8	MW WT vs. KO		4.1 ± 0.4	MW WT vs. KO	P = 0.4	8
KO	17.0 ± 3.4			62.3 ± 3.8		P = 0.05	3.6 ± 0.4			8
PC-Mixed: Purkinje Cells
WT	14.8 ± 2.3	Kruskal–Wallis	P = 0.00013	52.3 ± 11.8	MW WT vs. HEMI		12.5 ± 1.3	MW WT vs. HEMI	P = 0.38	8
HEMI	10.9 ± 2.8	MW WT vs. HEMI	P = 0.37	45.9 ± 17.4		P = 0.32	13.8 ± 1.4			9
KO	0.002 ± 0.002	MW KO vs. WT	P = 0.00008							9
		MW KO vs. HEMI	P = 0.00004
PC-Mixed: Molecular Layer Interneurons
WT	21.3 ± 4.5	MW WT vs. KO	P = 0.84	63.1 ± 10.5	MW WT vs. KO		4.3 ± 0.4	MW WT vs. KO	P = 0.14	6
KO	17.8 ± 1.6			50.3 ± 3.5		P = 0.53	4.0 ± 0.2			7
Global: Purkinje Cells
WT	16.5 ± 1.3	Kruskal–Wallis	P = 0.000124	106.7 ± 30.5	MW WT vs. HEMI		15.3 ± 1.6	MW WT vs. HEMI	P = 0.92	6
HEMI	14.7 ± 1.2	MW WT vs. HEMI	P = 0.71	58.1 ± 5.7		P = 0.32	15.3 ± 1.5			20
KO	0.01 ± 0.005	MW KO vs. WT	P = 0.0007							8
		MW KO vs. HEMI	P = 0.0000006
Global: Molecular Layer Interneurons
WT	13.7 ± 2.9	MW WT vs. KO	P = 0.02	52.9 ± 6.6	MW WT vs. KO		4.3 ± 0.2	MW WT vs. KO	P = 0.0007	6
KO	4.5 ± 1.1			23.9 ± 2.1		P = 0.0013	12.2 ± 1.1			8

Average (±SE) values and statistical comparisons of inhibitory postsynaptic currents (IPSCs) by cell type and mouse line. Note that no values are given for amplitude or decay for Purkinje cells from KO animals, and one cell was excluded from PC-Mixed-HEMI decay analysis, due to too few IPSCs. HEMI, hemizygous; KO, knockout; MW, Mann–Whitney tests; PC, Purkinje cell; WT, wild-type.