Fig 8.
Nocifensive reflex tests for Tac1Cre mice that received intraspinal injections of AAVs coding for either TeLC or eGFP. (A–C) Results for the dry ice, Hargreaves and von Frey tests, respectively. For the cold (Dry ice) and heat (Hargreaves) tests, the mice that received TeLC had significantly increased withdrawal latency for the ipsilateral hindlimb when comparing their pre- and post-operative values (p < 0.0001 and <0.001, respectively, 3-way ANOVA followed by Tukey's multiple comparisons test). No significant differences were found for the ipsilateral von Frey test in the TeLC-injected mice, for any of the contralateral tests in these mice or for either ipsilateral or contralateral tests in the eGFP-injected mice. Plots show mean and standard deviation. Individual paired values for each mouse are shown with grey lines.