Table 3.
Descriptive statistics (median and IQR) on the clinical biomarkers defined in this study covering blood counts, key biochemistry markers and physical measurements
| Phenotype | Category | UKB id | Units | Eng. Vision events | Eng. Vision median (IQR) | Scotland events | Scotland median (IQR) | Eng. TPP events | Eng. TPP median (IQR) | Wales events | Wales median (IQR) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ALP | Blood biochemistry | 30610 | U/L | 147431 | 73.00 (27.00) | 65 017 | 74.00 (28.00) | 907 659 | 74.00 (31.00) | 169 068 | 73.00 (27.00) |
| ALT | Blood biochemistry | 30620 | U/L | 114591 | 23.00 (14.00) | 54 724 | 20.00 (12.00) | 891 694 | 23.00 (13.00) | 92 361 | 22.00 (13.00) |
| Albumin | Blood biochemistry | 30600 | g/L | 144475 | 42.00 (4.00) | 33 063 | 43.00 (5.00) | 954 748 | 42.00 (5.00) | 164 884 | 42.00 (5.00) |
| CRP | Blood biochemistry | 30710 | mg/L | 23549 | 2.00 (3.00) | 2510 | 3.00 (4.00) | 89 406 | 4.00 (3.00) | 18 104 | 4.00 (3.30) |
| Calcium | Blood biochemistry | 30680 | mmol/L | 54796 | 2.34 (0.14) | 7367 | 2.33 (0.14) | 282 652 | 2.35 (0.14) | 42 470 | 2.35 (0.14) |
| Cholesterol | Blood biochemistry | 30690 | mmol/L | 140222 | 5.20 (1.60) | 75 828 | 5.00 (1.70) | 978 057 | 5.10 (1.70) | 138 801 | 5.10 (1.60) |
| Creatinine | Blood biochemistry | 30700 | umol/L | 164360 | 79.00 (23.00) | 102 491 | 75.00 (22.00) | 1 147 028 | 81.00 (23.00) | 204 486 | 76.00 (21.00) |
| Glucose | Blood biochemistry | 30740 | mmol/L | 41394 | 5.10 (0.90) | 17 603 | 5.10 (1.10) | 282 383 | 5.10 (1.00) | 28 830 | 5.20 (1.10) |
| HDL | Blood biochemistry | 30760 | mmol/L | 121635 | 1.40 (0.50) | 46 453 | 1.40 (0.57) | 764 837 | 1.40 (0.52) | 92 854 | 1.30 (0.50) |
| HbA1c | Blood biochemistry | 30750 | mmol/mol | 33799 | 40.00 (6.00) | 5915 | 44.00 (8.00) | 175 995 | 40.00 (7.00) | 21 659 | 41.00 (9.00) |
| Total bilirubin | Blood biochemistry | 30840 | umol/L | 137775 | 9.00 (5.00) | 64 802 | 9.00 (5.00) | 903 641 | 10.00 (6.00) | 140 003 | 9.00 (5.00) |
| Triglycerides | Blood biochemistry | 30870 | mmol/L | 116308 | 1.30 (0.90) | 40 272 | 1.40 (0.93) | 717 562 | 1.37 (0.90) | 128 464 | 1.36 (0.90) |
| Urea | Blood biochemistry | 30670 | mmol/L | 148897 | 5.50 (1.80) | 75 630 | 5.60 (1.90) | 1 022 366 | 5.50 (1.90) | 58 332 | 5.30 (1.80) |
| Basophills | Blood count | 30160 | 10^9/L | 129939 | 0.02 (0.10) | 53 759 | 0.02 (0.05) | 832 814 | 0.02 (0.06) | 138 889 | 0.03 (0.10) |
| Eosinophills | Blood count | 30150 | 10^9/L | 130840 | 0.20 (0.10) | 52 681 | 0.15 (0.12) | 828 186 | 0.16 (0.12) | 142 025 | 0.20 (0.12) |
| Hematocrit perc | Blood count | 30030 | % | 4055 | 41.10 (5.10) | 11 | 45.00 (5.45) | 11 971 | 41.70 (5.30) | 11 192 | 41.20 (5.00) |
| Hemoglobin conc | Blood count | 30020 | g/dL | 78815 | 13.70 (1.80) | 21 512 | 13.60 (1.90) | 903 286 | 13.70 (1.70) | 92 144 | 13.70 (1.80) |
| Lymphocytes | Blood count | 30120 | 10^9/L | 133853 | 1.80 (0.80) | 50 032 | 1.79 (0.82) | 842 332 | 1.89 (0.80) | 142 637 | 1.80 (0.80) |
| MCHb conc | Blood count | 30060 | g/dL | 64138 | 33.50 (1.40) | 28 062 | 33.50 (1.70) | 607 386 | 33.40 (1.40) | 33 023 | 33.60 (1.30) |
| MCV | Blood count | 30040 | fL | 136768 | 91.00 (6.00) | 54 055 | 90.00 (6.30) | 872 756 | 90.90 (6.10) | 147 161 | 91.00 (6.00) |
| Monocytes | Blood count | 30130 | 10^9/L | 133696 | 0.50 (0.20) | 52 727 | 0.50 (0.27) | 839 930 | 0.50 (0.21) | 141 545 | 0.50 (0.20) |
| Neutrophils | Blood count | 30140 | 10^9/L | 133588 | 3.40 (1.65) | 53 374 | 3.57 (1.86) | 845 892 | 3.50 (1.79) | 143 045 | 3.50 (1.71) |
| Platelets | Blood count | 30080 | 10^9/L | 137935 | 244.00 (84.00) | 55 317 | 249.00 (85.00) | 879 866 | 250.00 (84.00) | 145 591 | 251.00 (83.00) |
| RBC | Blood count | 30010 | 10^12/L | 135140 | 4.50 (0.58) | 54 030 | 4.47 (0.63) | 869 832 | 4.55 (0.59) | 146 016 | 4.52 (0.58) |
| WBC | Blood count | 30000 | 10^9/L | 140068 | 6.10 (2.25) | 55 830 | 6.20 (2.50) | 892 739 | 6.25 (2.30) | 147 751 | 6.20 (2.30) |
| DBP | Physical measures | 4079 | mmHg | 357987 | 80.00 (14.00) | 393 765 | 80.00 (13.00) | 2 833 375 | 80.00 (15.00) | 417 257 | 80.00 (14.00) |
| FEV1 | Physical measures | 3063 | L | 6238 | 2.08 (0.99) | 1430 | 1.79 (0.95) | 47 847 | 2.03 (1.04) | 6214 | 2.00 (1.04) |
| FVC | Physical measures | 3062 | L | 2792 | 2.95 (1.29) | 233 | 2.96 (1.15) | 32 277 | 3.00 (1.31) | 3778 | 2.89 (1.26) |
| Height | Physical measures | 50 | cm | 144 | 168.00 (13.12) | 63 262 | 167.00 (14.00) | 1069 | 166.00 (15.00) | 27 449 | 167.64 (14.98) |
| SBP | Physical measures | 4080 | mmHg | 358071 | 136.00 (22.00) | 212 521 | 135.00 (21.00) | 2 836 175 | 136.00 (22.00) | 418 084 | 137.00 (23.00) |
| Weight | Physical measures | 21002 | Kg | 142704 | 77.00 (23.50) | 181 172 | 77.90 (23.32) | 1 137 892 | 78.00 (23.50) | 148 988 | 80.00 (25.00) |
Note: Statistics were stratified by data provider: 1 = England Vision, 2 = Scotland EMIS and Vision, 3 = England TPP and 4 = Wales.
ALP: alanine aminotransferase level; ALP: alkaline phosphatase level; CRP: C-reactive protein; DBP: diastolic blood pressure; FEV1: forced expiratory volume in 1 second; FVC: full vital capacity; HDL: high-density lipoprotein; MChb conc: mean corpuscular hemoglobin concentration; MCV: mean corpuscular volume; RBC: red blood cell; SBP: systolic blood pressure; WBC: white blood cell.