Table 1.

In vitro metabolic stability of NPD-1246: percentage of parent compound remaining over time in the presence of mouse liver microsomes.

% Parent compound remaining upon incubation
Phase I/II	Time (min)	NPD-1246		Diclofenac
		Average	SD	Average	SD
CYP450-NADPH	0	100	−	100	−
	15	66	5	87	2
	30	27	9	70	6
	60	8	2	48	1
		(n = 2)		(n = 2)
UGT enzymes	0	100	−	100	−
	15	111	4	41	1
	30	111	2	44	8
	60	106	5	34	2
		(n = 2)		(n = 2)