Skip to main content
. Author manuscript; available in PMC: 2021 Oct 5.
Published in final edited form as: Chem Soc Rev. 2020 Oct 5;49(19):7167–7199. doi: 10.1039/d0cs00560f

Fig. 15.

Fig. 15

RNA-targeted small molecules inhibit translation of traditionally undruggable proteins. (A) Schematic depiction of α-synuclein-mediated disease pathway. (B) Structure of Synucleozid, an Inforna-designed small molecule that binds the A-bulge of the SNCA IRE that regulates translation of the mRNA. (C) Synucleozid targets the IRE structure of SNCA mRNA and represses α-synuclein protein expression by inhibiting ribosomal assembly onto the SNCA transcript.