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. Author manuscript; available in PMC: 2021 Oct 5.
Published in final edited form as: Chem Soc Rev. 2020 Oct 5;49(19):7167–7199. doi: 10.1039/d0cs00560f

Fig. 16.

Fig. 16

Small molecule-bleomycin A5 conjugates cleave disease-causing RNAs in a targeted manner. (A) Structure of Bleomycin A5. (B) TGP-96-Bleo targets and cleaves oncogenic pri-miR-96. (C) Targeted degradation of r(CUG)exp by Cugamycin and r(CCUG)exp by 5-Bleo. (D) Targeted degradation of the pri-miR-17-92 cluster by TGP-17-92 Bleo.