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. Author manuscript; available in PMC: 2021 Oct 5.
Published in final edited form as: Chem Soc Rev. 2020 Oct 5;49(19):7167–7199. doi: 10.1039/d0cs00560f

Fig. 17.

Fig. 17

Ribonuclease targeting chimeras (RIBOTACs) degrade disease-causing RNAs in a targeted manner. (A) Structures of first- and second-generation RNase L recruiting modules and schematized monomeric RNase L. (B) RIBOTAC-mediated degradation of oncogenic pri-miR-96, pre-miR-210, and pre-miR-21.