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. Author manuscript; available in PMC: 2021 Oct 5.
Published in final edited form as: Chem Soc Rev. 2020 Oct 5;49(19):7167–7199. doi: 10.1039/d0cs00560f

Fig. 3.

Fig. 3

Small molecule inhibition of lncRNAs. (A) Chemical structure of ADQ. (B) ADQ binds to the 5′ domain of HOTAIR and suppresses trimethylation of histone H3 lysine 27 (H3K27) in the promoter region of nemo like kinase (NLK) by weakening HOTAIR’s ability to recruit and bind enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), the enzymatic component of the PRC2 complex, thus restoring expression of NLK. (C) MALAT1 triple helix structure. (D) Chemical structures of MALAT1 small molecule binders.