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. Author manuscript; available in PMC: 2021 Oct 5.
Published in final edited form as: Chem Soc Rev. 2020 Oct 5;49(19):7167–7199. doi: 10.1039/d0cs00560f

Fig. 9.

Fig. 9

RNA-templated ligand oligomerization catalyzed by r(CUG)exp. (A) In cellulis click chemistry, templated by the RNA repeat expansion, forms an oligomeric compound on-site, that is bound to the r(CUG)exp RNA target. (i) MBNL1 sequestered by r(CUG)exp is released upon binding of the dimeric click compound. (ii) The azide terminus of one dimer reacts with the alkyne terminus of another dimer in close proximity to synthesize an oligomer in cellulis. (B) Structures of the RNA binding motif and dimeric click compound that oligomerizes in cellulis.