Table 1.

Anti-proliferative activity of compounds 7, 8a–c, 9 and 10a–e against human cancer A-549, MDA-MB-231 and HCT-116 cell lines.

Comp.	R	X	IC50 (µM)a
			A-549	MDA-MB-231	HCT-116
7	CH2CH3	5-Cl	50.0 ± 3.37	27.6 ± 1.76	19.7 ± 1.28
8a	CH2CH2CH3	5-CH3	7.3 ± 0.42	4.7 ± 0.28	2.6 ± 0.17
8b	CH2CH2CH3	5-OCF3	9.2 ± 0.78	8.9 ± 0.61	19.1 ± 1.34
8c	CH2CH2CH3	5-NO2	12.3 ± 1.05	15.6 ± 0.98	6.4 ± 0.50
9	CH(CH3)2	H	31.7 ± 2.27	10.4 ± 0.80	28.2 ± 1.73
10a	CH2CH=CH2	H	17.3 ± 1.19	11.7 ± 1.04	7.7 ± 0.68
10b	CH2CH=CH2	5-F	59.9 ± 3.58	54.0 ± 4.17	36.3 ± 2.35
10c	CH2CH=CH2	7-F	43.8 ± 2.96	35.4 ± 1.92	7.3 ± 0.47
10d	CH2CH=CH2	5-Cl	53.1 ± 4.13	42.9 ± 2.51	28.5 ± 1.59
10e	CH2CH=CH2	5-OCF3	40.2 ± 1.88	51.8 ± 3.77	37.4 ± 2.06
Dox.	-	-	2.3 ± 0.17	4.5 ± 0.29	3.7 ± 0.24

^aIC₅₀ values are the mean ± SE of 3 discrete experiments.