Table 5.
Inhibitory activities of compound 8a against CDK2 and Bcl-2.
| Compound | IC50 (μM)a |
|
|---|---|---|
| CDK2 | Bcl-2 | |
| 8a | 0.85 ± 0.03 | 0.46 ± 0.02 |
| Roscovitine | 0.1 ± 0.01 | – |
| Venetoclax | – | 0.09 ± 0.01 |
aIC50 values are the mean ± SE of three separate experiments.
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