Table 1.
Study design and outcome of VSBV-1 infections experiments carried out in Lewis rats.
| Virus isolate | group ID | Age of animals | Inoculation route | Number of animals | Study duration | Tissue VSBV-1 RT-qPCR positive | Bornavirus reactive antibodies | Histological changes related to bornaviruses |
|---|---|---|---|---|---|---|---|---|
| Alvin | 1 | adult | intracerebrally | 15 | 90/140 days | 0/15 | 0/15 | 0/15 |
| 2 | adult | intranasally | 15 | 90/140 days | 0/15 | 10/15 | 0/15 | |
| 3 | adult | subcutanously | 15 | 90/140 days | 0/15 | 0/15 | 0/15 | |
| 4 | neonatal | intracerebrally | 15 (+3 mothers) | 90/140 days | 3/15 | 6/15 (+2/3) | 3/15 | |
| 5 | neonatal | intranasally | 15 (+3 mothers) | 90/140 days | 0/15 | 1/15 (+1/3) | 0/15 | |
| 6 | neonatal | subcutaneously | 15 (+3 mothers) | 90/140 days | 0/15 | 4/15 (+1/3) | 0/15 | |
| Simon | D | neonatal | intracerebrally | 10 (+1 mother) | 112 days | 4/10 | 4/10 | n.d. |
| Theodore | E | neonatal | intracerebrally | 4 (+1 mother) | 112 days | 2/4 | 2/4 | n.d. |
n.d.= = not done.