Table 3.

Cholinesterase inhibitory activities of the methanol and aqueous extracts of different parts of Garcinia mangostana.

Sample	% of inhibition at 100 µg/mL		IC50 (µg/mL)		Selectivity
	AChE	BCHE	AChE	BChE	AChE	BChE
Methanol extract
Pericarp	82.19 ± 2.89	74.63 ± 1.03	0.90 ± 0.10	1.94 ± 0.14	2.15	0.46
Calyx	92.92 ± 3.86	94.10 ± 4.12	9.71 ± 1.20	0.37 ± 0.04	0.04	26.24
Aril	22.00 ± 0.48	5.26 ± 0.37	ND	ND	ND	ND
Stalk	65.54 ± 3.51	80.11 ± 0.74	22.81 ± 0.72	20.84 ± 0.02	0.91	1.09
Leaves	32.76 ± 2.09	76.46 ± 1.67	ND	25.83 ± 0.77	ND	ND
Bark	83.90 ± 1.35	76.46 ± 0.18	7.88 ± 0.82	19.89 ± 2.68	2.52	0.39
Stem	94.0 3 ± 1.75	89.95 ± 0.78	22.64 ± 0.77	1.82 ± 0.16	0.08	12.44
Aqueous extract
Pericarp	55.37 ± 1.53	82.59 ± 0.09	52.74 ± 8.98	11.14 ± 0.61	0.21	4.73
Calyx	17.90 ± 3.13	NI	ND	ND	ND	ND
Aril	NI	NI	ND	ND	ND	ND
Stalk	59.20 ± 3.60	2.36 ± 0.37	72.22 ± 2.58	ND	ND	ND
Leaves	15.70 ± 0.93	65.19 ± 0.56	ND	38.81 ± 1.84	ND	ND
Bark	NI	15.09 ± 8.56	ND	ND	ND	ND
Stem	11.60 ± 1.16	11.23 ± 0.93	ND	ND	ND	ND
Galantamine			0.27 ± 0.07	5.55 ± 0.24	20.55	0.04

Each value represents mean ± SD of triplicates. NI: No inhibition at 100 µg/mL. ND: Not determined.

Selectivity against AChE: IC₅₀BChE/IC5₀AChE.

Selectivity against BChE: IC₅₀AChE/IC5₀BChE.