Table 5.
Summary population attributable risks (PAR) for established RCC risk factors and chronic kidney disease by race and sex in the USKC study
| Establisheda RCC risk factors | Establisheda RCC risk factors and chronic kidney disease | |||||
|---|---|---|---|---|---|---|
| PAR%a | (95% CI) |
Hypothetical RCC incidence in absence of exposureb (95% CI) |
PAR%a | (95% CI) |
Hypothetical RCC incidence in absence of exposureb (95% CI) |
|
| Race and sex | ||||||
| White females | 55.4 | (35.9, 75.0) | 11.1 (6.2, 15.9) | 56.4 | (35.5, 77.3) | 10.8 (5.6, 16.0) |
| White males | 47.7 | (23.9, 71.5) | 26.0 (14.2, 37.8) | 48.4 | (23.7, 73.2) | 25.6 (13.3, 37.9) |
| White overall | 52.0 | (35.5, 68.4) | 17.5 (11.5, 23.5) | 52.7 | (35.5, 70.0) | 17.2 (11.0, 23.5) |
| Black females | 63.4 | (19.5, 107.2) | 10.0 (−2.0, 21.9) | 72.8 | (22.9, 122.8) | 7.4 (−6.2, 21.0) |
| Black males | 75.9 | (54.5, 97.3) | 14.6 (1.6, 27.6) | 86.5 | (60.0, 112.9) | 8.2 (−7.9, 24.3) |
| Black overall | 70.5 | (53.2, 87.7) | 12.4 (5.1, 19.6) | 80.5 | (59.6, 101.5) | 8.1 (−0.6, 16.9) |
Abbreviations: USKC, US Kidney Cancer Study; PAR, population attributable risk; CI, confidence interval.
Established RCC risk factors are hypertension, smoking, and obesity.
PARs were calculated using sample weighted unconditional logistic regression models adjusted for education, age, study center and family history of cancer.
Renal cancer incidence rate per 100,000 per year in the absence of exposure = [SEER incidence rate*(1-PAR%)] by race and sex. SEER incidence rates of microscopically-confirmed cases of adenocarcinoma of the kidney (renal parenchyma) among individuals ages 50-79 from 2002-2006 were: white females 24.8, white males 49.7, white overall 36.5, black females 27.2, black males 60.7, black overall 41.8 per 100,000 per year.