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. Author manuscript; available in PMC: 2020 Dec 4.
Published in final edited form as: Nucleosides Nucleotides Nucleic Acids. 2019 Oct 9;39(1-3):204–224. doi: 10.1080/15257770.2019.1671594

Figure 4.

Figure 4.

Intracellular accumulation of total NI-TP metabolite and intact prodrug of DAPN-PD, IDX-184, BMS-986094 and sofosbuvir at 4 and 8 h in human cardiomyocytes. (A) Intracellular level of total NI-TP metabolite(s) of DAPN-PD, IDX-184, BMS-986094 and sofosbuvir and (B) Intracellular level of intact prodrug of DAPN-PD, IDX-184, BMS-986094 and sofosbuvir at 4 h and 8 h in human cardiomyocytes at (10 μM, 37 °C). Values represent the mean of three replicates. NI-TP: nucleoside 5’-triphosphate. For DAPN-PD, total NI-TP is 2’-C-Me-DAPN-TP and 2’-C-Me-GTP. For IDX-184, NI-TP is 2’-C-Me-GTP. For BMS-986094, total NI-TP is 2’-C-Me-GTP and 2’-C-Me-6-OMe-GTP. For sofosbuvir, NI-TP is 2’-F-2’-C-Me-UTP.