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. Author manuscript; available in PMC: 2020 Dec 4.
Published in final edited form as: Nucleosides Nucleotides Nucleic Acids. 2019 Oct 9;39(1-3):204–224. doi: 10.1080/15257770.2019.1671594

Scheme 2.

Scheme 2.

Synthesis of DAPN-PD. Reagents and conditions: (a) DBU, TMSOTf, CH3CN, 65 °C, 3 h, 79.5%; (b) NH3/MeOH, rt, 12 h, 69.9%; (c) 4, THF, t-BuMgCl, 0 °C to rt, 6 h, 80%; (d) NaN3, (Bu)4NI, DMF, 80 °C, 18 h; (e) H2, 20% Pd(OH)2, i-PrOH, rt, 52% (two steps).