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(A) Trigeminal nucleus with atrophic and reduced neuronal population (arrows). (B) Axonal loss in the posterior roots of the spinal cord. (C) Axonal loss in the anterior roots of the spinal cord. (D) TDP-43–positive cytoplasmic inclusions in the lower motor neurons (arrows), observed by immunohistochemistry. TDP-43 = TAR-DNA binding protein.
