Table 3:
GO annotations using the top genes and the enriched pathways.
| Biological Process GO Terms | P-value | |
|---|---|---|
| Postsynaptic intermediate filament cytoskeleton organization | 9.56E-06 | |
| Neurofilament cytoskeleton organization | 5.73E-05 | |
| Postsynaptic cytoskeleton organization | 2.17E-04 | |
| Intermediate filament cytoskeleton organization | 8.73E-03 | |
| Intermediate filament-based process | 9.28E-03 | |
| Neurofilament bundle assembly | 1.43E-02 | |
| Molecular Function GO Terms | P-value | |
| Structural constituent of postsynaptic intermediate filament cytoskeleton | 3.00E-06 | |
| Structural constituent of synapse | 1.99E-04 | |
| Structural constituent of cytoskeleton | 2.52E-02 | |
| Cellular Component GO Terms | P-value | |
| Neurofilament | 2.82E-05 | |
| Postsynaptic intermediate filament cytoskeleton | 1.40E-03 | |
| Schaffer collateral – CA1 synapse | 8.07E-03 | |
| Postsynaptic cytoskeleton | 1.05E-02 | |
| Upregulated pathways in phenotype AD | Gene Set Size | Enrichment Score |
| Neuronal system | 276 | 2.66 |
| Transmission across chemical synapses | 184 | 2.5 |
| Voltage gated potassium channels | 43 | 2.44 |
| Potassium channels | 98 | 2.43 |
| Neurotransmitter receptor binding and transmission in postsynaptic cell | 135 | 2.34 |
| Neurotransmitter release cycle | 34 | 2.11 |
| Axon guidance | 243 | 1.7 |
| Down regulated pathways in phenotype AD | Gene Set Size | Enrichment Score |
| Translation | 209 | −2.6 |
| SRP dependent cotranslational protein targeting to membrane | 169 | −2.58 |
| Peptide chain elongation | 145 | −2.5 |
| Metabolism of RNA | 316 | −2.26 |
| DNA strand elongation | 30 | −1.93 |
| Synthesis of DNA | 91 | −1.91 |
| Metabolism of proteins | 484 | −1.9 |
| Lipoprotein metabolism | 28 | −1.88 |