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Uses of optical/CT along the preclinical translational spectrum. 3D OI/ CT imaging allows for precise localization of the intracranial implanted NIR-labeled GBM cells. After GBM cell implantation, 3D OI/CT imaging enables visualization of the tumor growth and intracranial location of the tumor. 3D OI/CT imaging using Cy7 labeled albumin validates BBB opening with HIFU or CED drug delivery allowing visualization of drug distribution.
