Table 4.

Twenty-one SNPS that showed suggestive/significant associations with BP in gene-LRS analysis in FHS

Locus	Chr:position†	SNP	Genomic location¶	Effect Allele	EAF	BP trait	Exposure	${\mathit{\beta }}_{\mathit{G}}$	${\mathit{S}\mathit{E}}_{\mathit{G}}$	${\mathit{P}}_{\mathit{G}}$	${\mathit{\beta }}_{\mathit{G}\mathit{E}}$	${\mathit{S}\mathit{E}}_{\mathit{G}\mathit{E}}$	${\mathit{P}}_{\mathit{G}\mathit{E}}$	${\mathit{P}}_{\mathit{J}\mathit{o}\mathit{i}\mathit{n}\mathit{t}2\mathit{d}\mathit{f}}$
1	2:134312960	rs1368091	Intronic NCKAP5	G	0.281	DBP	DLRS	−1.15	0.28	2.85E-05	1.73	0.35	7.23E-07	4.16E-06
2	3:123923233	rs7652065	Intronic KALRN	A	0.376	SBP	DLRS	−1.67	0.38	1.48E-05	2.43	0.50	8.82E-07	4.03E-06
	3:123923922	rs1444768	Intronic KALRN	G	0.376	SBP	DLRS	−1.66	0.38	1.48E-05	2.43	0.49	8.74E-07	4.01E-06
	3:123927014	rs880000	Intronic KALRN	G	0.377	SBP	DLRS	−1.62	0.38	2.00E-05	2.40	0.49	8.63E-07	4.32E-06
	3:123930542	rs1444757	Intronic KALRN	C	0.377	SBP	DLRS	−1.62	0.38	1.99E-05	2.40	0.49	9.13E-07	4.54E-06
3	3:143028187	rs17636599	Intronic SLC9A9	T	0.011	SBP	QLRS	3.39	1.61	3.59E-02	−2.41	0.51	2.28E-06	1.80E-07
4	4:180139179	rs10520420	Intergenic	T	0.988	DBP	DLRS	3.98	0.74	9.23E-08	−4.06	1.03	7.71E-05	6.34E-07
	4:180151019	rs4146838	Intergenic	G	0.988	DBP	DLRS	4.07	0.73	3.01E-08	−4.16	1.02	4.63E-05	2.13E-07
	4:180164081	rs969219	Intergenic	A	0.988	DBP	DLRS	4.19	0.72	6.32E-09	−4.29	1.01	2.31E-05	4.69E-08
	4:180178378	rs11131920	Intergenic	G	0.010	DBP	DLRS	−5.10	0.67	4.01E-14	5.29	0.99	8.95E-08	3.71E-13
	4:180179576	rs11131921	Intergenic	T	0.010	DBP	DLRS	−5.09	0.67	4.19E-14	5.29	0.99	9.14E-08	3.90E-13
5	7:158848821	rs3793217	Intronic VIPR2	A	0.865	DBP	QLRS	−1.14	0.33	6.55E-04	0.62	0.12	1.44E-07	3.34E-07
6	8:25374910‡	rs2012485	Intergenic CDCA2	C	0.961	SBP	QLRS	−4.31	1.02	2.62E-05	1.80	0.37	8.23E-07	4.51E-06
7	8:54274100	rs7001769	Intergenic OPRK1	T	0.828	SBP	QLRS	2.23	0.51	1.18E-05	−0.35	0.19	6.20E-02	7.63E-07
	8:54277247	rs7465458	Intergenic OPRK1	A	0.828	SBP	QLRS	2.24	0.51	1.03E-05	−0.35	0.19	5.81E-02	6.94E-07
8	11:11395489§	rs10047474	Intronic GALNT18	T	0.457	DBP	QLRS	1.81	0.34	0.00E+00	−0.48	0.12	5.80E-05	4.47E-07
9	11:49202187‡	rs7124497	Intronic FOLH1	G	0.950	SBP	DLRS	−1.06	0.97	2.73E-01	4.41	1.16	1.47E-04	7.40E-07
10	12:133441378	rs4303268	Intronic CHFR	G	0.892	SBP	QLRS	−3.68	0.83	9.67E-06	1.43	0.29	7.73E-07	4.09E-06
11	15:64315336	rs12442060	Intronic DAPK2	C	0.635	SBP	DLRS	1.68	0.40	2.53E-05	−2.55	0.51	5.39E-07	3.15E-06
	15:64316458	rs172995	Intronic DAPK2	A	0.715	SBP	DLRS	1.80	0.44	3.35E-05	−2.76	0.55	6.52E-07	3.93E-06
12	18:30053150	rs11081767	Intergenic GAREM	A	0.466	DBP	QLRS	1.11	0.24	2.00E-06	−0.43	0.09	7.14E-07	2.24E-06

^†Chr:position: based on human genome build 37.

^‡Within boundaries of known loci previously reported to be associated with BP (in published literature between 2011 and 2019; see S?).

^§Within boundaries of locus detected in CHARGE Gene-Lifestyle Interactions Working Group’s large-scale study on gene-alcohol interactions on BP (Feitosa et al., 2018).

^¶Genomic location: sourced from FUMA GWAS (https://fuma.ctglab.nl). Nearest mapped gene is indicated for intergenic SNPs, while gene located within is indicated for intronic SNPs. No gene is specified for 5 SNPs because only unmapped/uncharacterized genes are located within 500 kb of these SNPs.

Genome-wide significant SNPs at P-value < 5 × 10⁻⁸ are in bold font. All other SNPs are suggestive at P-value < 1 × 10⁻⁶.

Abbreviations: Chr, chromosome; QLRS, quantitative lifestyle risk score; DLRS, dichotomous lifestyle risk score; EAF, effect allele frequency; ${\mathit{\beta }}_{\mathit{G}}$, genetic main effect; ${\mathit{S}\mathit{E}}_{\mathit{G}}$, standard error for genetic main effect; ${\mathit{P}}_{\mathit{G}}$, P-value for genetic main effect; ${\mathit{\beta }}_{\mathit{G}\mathit{E}}$, gene-environment interaction effect; ${\mathit{S}\mathit{E}}_{\mathit{G}\mathit{E}}$, standard error for gene-environment interaction effect; ${\mathit{P}}_{\mathit{G}\mathit{E}}$, P-value of 1 degree of freedom (DF) interaction test; ${\mathit{P}}_{\mathit{J}\mathit{o}\mathit{i}\mathit{n}\mathit{t}2\mathit{d}\mathit{f}}$, P-value of 2 DF Joint test.