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. 2020 Nov 16;9:e61265. doi: 10.7554/eLife.61265

Figure 9. Representation of the role of B2 RNA processing in amyloid pathology.

Figure 9.

Upon removal of the stress-generating stimulus, healthy cells restore the expression levels of Hsf1, specific B2 RNA regulated target genes and processing ratio of B2 RNAs returns to base levels. In contrast, in amyloid pathology, increased amyloid beta load acts as a continuous stimulus that causes the Hsf1 - B2 RNA – B2-SRG axis to ‘lock’ into an activated mode. ON/OFF represent active and suppressed SRG transcription, respectively.