TABLE 2.

Different panels for CRC screening.

Name	Sensitivity%	Specificity%	AUC	Technique	Algorithm	Sample	Case	Region	References
Fn, Pa, Pm	89.4	93.0	0.950	qPCR	LR	Feces	390	China	Wong et al., 2017a
Ps/EUB, Bf/EUB, Bt/EUB	80.0	90.0	0.837	qPCR	LR	Feces	333	Spain	Malagón et al., 2019
pks, Fn	89.7	61.0	NA	qPCR	DA	Feces	238	Sweden	Eklöf et al., 2017
Fn/Fp	95.0	71.3	0.914	qPCR	AR	Feces	549	China	Rezasoltani et al., 2018
Fn/Bb	84.6	92.3	0.911	qPCR	AR	Feces	549	China	Rezasoltani et al., 2018
Fn/Fp, Fn/Bb	80.8	85.6	0.910	qPCR	AR	Feces	549	China	Rezasoltani et al., 2018
Fn, Fp, Bb	92.5	83.5	0.943	qPCR	AR	Feces	549	China	Rezasoltani et al., 2018
5 OTUs	90.0	80.0	0.896	16SrDNA	LR	Feces	90	America	Zackular et al., 2014
6 OTUs	90.0	83.0	0.922	16SrDNA	LR	Feces	90	America	Zackular et al., 2014
22OTUs	81.2	97.1	0.673	16SrDNA	RF	Feces	490	Canada, United States	Baxter et al., 2016b
34 OTUs	51.7	97.1	0.847	16SrDNA	RF	Feces	490	Canada, United States	Baxter et al., 2016b
23 OTUs	70.0	92.8	0.829	16SrDNA	RF	Feces	490	Canada, United States	Baxter et al., 2016b
16 OTUs	53.0	96.0	0.900	16SrDNA	RF	Oral swabs	60	Ireland	Flemer et al., 2018
28 OTUs (16 oral swabs, 12 feces)	74.0	94.0	0.940	16SrDNA	RF	Feces and oral swabs	60	Ireland	Flemer et al., 2018
63 OTUs (29 oral swabs, 34 feces)	88.0	94.0	0.980	16SrDNA	RF	Feces and oral swabs	60	Ireland	Flemer et al., 2018
22 OTUs	58.0	92.0	0.840	Metagenomics	LR	Feces	156	France, Germany	Zeller et al., 2014
7 OTUs	87.0	83.7	0.886	Metagenomics	RF	Feces	128	China	Yu et al., 2017a
15 MLGs	NA	NA	0.983	Metagenomics	RF	Feces	96	Austria	Feng et al., 2015
16 OTUs	NA	NA	0.860	Metagenomics	RF	Feces	969	Meta	Thomas et al., 2019a
17 OTUs	60.1	84.8	0.804	Metagenomics	RF	Feces	424	Meta	Shah et al., 2018
30 OTUs	NA	NA	0.830	Metagenomics	RF	Feces	208	Meta	Yachida et al., 2019
8 taxa	NA	NA	0.750	16SrDNA	RF	Feces	492	Meta	Yachida et al., 2019
12 genus	NA	NA	0.846	16SrDNA	RF	Feces	1674	Meta	Sze and Schloss, 2018
18 OTUs	NA	NA	0.831	16SrDNA	RF	Feces	404	Canada, United States	Baxter et al., 2016a
32 OTUs	NA	NA	0.853	16SrDNA	RF	Feces	404	Canada, United States	Baxter et al., 2016a
41 OTUs	NA	NA	0.686	16SrDNA	RF	Feces	404	Canada, United States	Baxter et al., 2016a
12 phylotypes	NA	NA	0.831	16SrDNA	LEfSe	Mucosa	160	China	Nakatsu et al., 2015
18 OTUs	NA	NA	0.871	16SrDNA	RF	Mucosa	160	China	Nakatsu et al., 2015
38 phylotypes	NA	NA	0.846	16SrDNA	Dirichlet MM	Mucosa	160	China	Nakatsu et al., 2015
m3, Fn, Ch, Bc	85.2	80.2	0.907	qPCR	LR	Feces	1012	China	Liang et al., 2019
m3, Fn	NA	NA	0.891	qPCR	LR	Feces	1012	China	Liang et al., 2019
Fn, Ch, m7, Bc	92.8	79.8	0.886	qPCR	SLC	Feces	370	China	Liang et al., 2017
Fn, Ch, m7, Bc, Ri	74.3	88.9	0.843	qPCR	LR	Feces	128	China	Liang et al., 2017
17 IMG species	NA	NA	0.860	Metagenomics	IMG	Feces	128	China	Liang et al., 2017
7 species-level mOTUs	NA	NA	0.890	Metagenomics	mOTUs	Feces	128	China	Liang et al., 2017
27 MLG	NA	NA	0.960	Metagenomics	MLG	Feces	128	China	Liang et al., 2017
Fn, Pa, Pm (4 genes)	NA	NA	0.770	Metagenomics	CRC index	Feces	96	China, Denmark, Austrian, French	Yu et al., 2017a
22 genes	NA	NA	0.998	Metagenomics	RF	Feces	107	China	Yang et al., 2020
Cb, Cs	NA	NA	0.935	qPCR	RF	Feces	60	China	Yang et al., 2020
7 CRC-enriched bacteria	NA	NA	0.800	Metagenomics	SVM	Feces	526	Meta	Dai et al., 2018
55 species	NA	NA	0.830	Metagenomics	RF	Feces	181	Meta	Sze and Schloss, 2018

DA, Decision Abundance; AR, Abundance Rate; SLC, Simple linear combination; Dirichlet MM, Dirichlet multinomial mixtures; Clostridium hathewayi (Ch); Unclassified species (m7); Roseburia intestinalis (Ri); Bacteroides thetaiotaomicron (Bt).