Table 1.
Summary of the ubiquitin enzymes involved in regulating DCs maturation and function, as discussed in the text.
| Ubiquitin enzyme | Type | Expression in DCs | Target | Action in DCs | Related diseases | References |
|---|---|---|---|---|---|---|
| MARCH1 | E3 ligase | CD11c+DCs CD206+MoDCs | MHCII, CD86 | Inhibits DCs phenotypic maturation Affects antigen presentation Affects DCs-mediated T cell activation Promotes MoDCs migration |
(15–27) | |
| WWP2 | E3 ligase | DCs | MHCII | Inhibits DCs-mediated T cell activation | Salmonella infection | (28) |
| Hrd1 | E3 ligase | CD11c+DCs | BLIMP | Impairs DCs-mediated priming of CD4+ T cells | EAE | (29) |
| A20 | Deubiquitinase | CD11c+DCs | NEMO | Suppress DC maturation and cytokines production Maintains immune homeostasis Suppress T cells activation and differentiation Suppress B cells activation |
systemic autoimmunity disease |
(30–33) |
| PDLIM2 and MKRN2 | E3 ligase | CD11c+DCs | p65 | Suppress DC activation and cytokines production | (34–36) | |
| Trabid | Deubiquitinase | CD11c+DCs | Jmjd2d | Promotes DCs-mediated Th1 and Th17 cells differentiation | EAE | (37) |
| OTUB1 | Deubiquitinase | CD11c+DCs | UBC13 | Promotes DCs cytokines production | Infection | (38) |
| sCYLD | Deubiquitinase | CD11c+DCs | Promotes DCs cytokines production Promotes DCs-mediated CD8+T cell response and NK cells activation | Infection | (39) | |
| c-Cbl and Cbl-b | E3 ligase | BMDC | p105, p50 | Promotes BMDC cytokines production Maintains immune homeostasis |
(40–42) | |
| CRL4 DCAF2 | Deubiquitinase | CD11c+DCs | NIK | Inhibits DCs cytokines production and Th17 cells differentiation Maintains immune homeostasis |
Psoriasis EAE |
(43) |
| UCH-L1 | Deubiquitinase | CD11c+DCs | MHC I | Promotes DCs antigen cross-presentation | Listeria monocytogenes infection | (44) |
| CRL5 ASB2α | E3 ligase | CD11c+DCs | FLNa and FLNb | Promotes DCs migration | (45) |