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. 2020 Nov 20;11:605187. doi: 10.3389/fimmu.2020.605187

Figure 1.

Figure 1

Lung biopsies from patients with common variable immune deficiency (CVID)-related interstitial lung disease (ILD). (A) Patient 1: (i) lung biopsy section stained with hematoxylin and eosin (H&E), to show lack of alveolar spaces, and many lymphocytes infiltrating the interstitium (ii) shows staining for CD4+ cells that predominate, sometimes in nodules, (iii) shows scanty CD8+ cells (33). No granulomata or organizing pneumonia. (B) Patient 2: (i) lung biopsy section stained for CD3+ cells, showing that T-cells surround follicles and are additionally found in discreet nodules, (ii) shows the follicles to consist of CD20+ cells, with only scattered CD20+ B-cells in other areas. No granulomata or organizing pneumonia.