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. 2020 Nov 16;8:599376. doi: 10.3389/fcell.2020.599376

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Copyright © 2020 Ma, Sun, Pi, Wang, Sun, Yu, Shi and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sirt3 alleviated MSC senescence through ameliorating DNA damage and intracellular MDA contents. DNA damage was determined by comet assay in both natural and premature senescent cells upon Sirt3 replenishment (A,B). Fluorescent images and the quantitative analysis of comet-positive cells (C,D) and olive tail moments (OTM) (E,F). (G,H) The levels of intracellular MDA were determined by colorimetry in the old group (G) and H₂O₂-treated group (H). Data are expressed as mean ± SD, n = 3. *P < 0.05, **P < 0.01 vs. old or H₂O₂.