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. 2020 Nov 17;11:598845. doi: 10.3389/fphys.2020.598845

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Copyright © 2020 Zavala, Voliotis, Zerenner, Tabak, Walker, Li, Terry, Lightman, O'Byrne and Tsaneva-Atanasova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enduring and transient dynamic changes under hiCORT. (A) CORT and PG rhythms in physiological conditions. (B) Mean PG frequency and maximum CORT levels elicited by 2 h long hypothalamic stressors arriving at different times across the estrous cycle. (C) Under hiCORT, the range of CORT levels is increased and the estrous cycle peak is delayed by ~21% compared to physiological values. (D) Mean PG frequency and maximum CORT elicited by 2 h long stressors under hiCORT. In this scenario, the period in which PG activity remains unchanged by stressors starts about half a day later and is shortened compared to normal physiological conditions.