Table 1.
Single-nucleotide polymorphisms investigated in this study.
| Function | Gene | Chromosome | rs number | Location (Consequence) |
|---|---|---|---|---|
| Pattern recognition receptors | Peptidoglycan recognition protein 2 (PGLYRP2) | 19 | rs892145 | Exon (Missense) |
| Peptidoglycan recognition protein 4 (PGLYRP4) | 1 | rs10888557 | 4KB upstream | |
| Toll like receptor 1 (TLR1) | 4 | rs4833095 | Exon (Missense) | |
| Toll like receptor 2 (TLR2) | 4 | rs3804099 | Exon (Synonymous) | |
| Toll like receptor 4 (TLR4) | 9 | rs4986790 | Exon (Missense) | |
| rs7873784 | 3' UTR | |||
| Cluster of differentiation 14 (CD14) | 5 | rs2569190 | Intron | |
| Intestinal barrier integrity | Mucin 1 (MUC1) | 1 | rs4072037 | Exon (Synonymous) |
| Mucin 2 (MUC2) | 11 | rs11825977 | Exon (Missense) | |
| Claudin 2 (CLDN2) | X | rs12008279 | Intron | |
| rs12014762* | 3' UTR | |||
| Claudin 4 (CLDN4) | 7 | rs8629 | 5' UTR |
*
Variant spans CLDN2 and MORC4 genes.