Table 4.
Generalized linear models investigating target SNPs and estimated mean age of PD symptom onset in enriched APDR cohort.
| Gene | SNP | GLMs in APDR (p-value) | ||
|---|---|---|---|---|
| Naïve | Corrected (Toxins) | Corrected (Smoking) | ||
| PGLYRP2 | rs892145 | 0.634 | 0.492 | 0.399 |
| PGLYRP4 | rs10888557 | 0.029* | 0.029* | 0.030* |
| TLR1 | rs4833095 | 0.991 | 0.985 | 0.999 |
| TLR2 | rs3804099 | 0.934 | 0.928 | 0.887 |
| TLR4 | rs4986790 | 0.246 | 0.254 | 0.289 |
| TLR4 | rs7873784 | 0.663 | 0.666 | 0.747 |
| CD14 | rs2569190 | 0.187 | 0.146 | 0.153 |
| MUC1 | rs4072037 | 0.058 | 0.076 | 0.089 |
| MUC2 | rs11825977 | 0.792 | 0.652 | 0.648 |
| CLDN2 | rs12008279 | 0.971 | 0.489 | 0.531 |
| CLDN2 | rs12014762 | 0.490 | 0.626 | 0.615 |
| CLDN4 | rs8629 | 0.328 | 0.292 | 0.311 |
*
p < 0.05 from test of model. Corrected (toxins), lifetime toxin exposure and gender; corrected (smoking), lifetime smoking status and gender. Bold values and *indicate p < 0.05 from test of model.