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Protein ubiquitination in ferroptosis. Both SLC7A11 expression and its stability were regulated by ubiquitination in ferroptosis. Ubiquitination of H2A and H2B was critical for SLC7A11 expression, while OTUB1 deubiquitinating SLC7A11 increases its stability. Erastin not only inhibits the activity of system Xc− but also regulates the ubiquitination of VDAC2/3 via Nedd4 to promote ferroptosis.
