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PKM2 is required for breast cancer cell viability. (a) PKM2 protein level was reduced by PKM2 siRNA, and GAPDH was used as a loading control. (b) Q-RT PCR analysis of PKM2 mRNA levels normalized to GAPDH in the control group and PKM2-KD cells. (c), (d) Cell viability was measured by CCK-8 assay in MDA-MB-231 and MCF-7 cells following PKM2 silencing by siRNA. (e), (f) Colony formation of PKM2-knockdown MDA-MB-231 and MCF-7cells was reduced (∗∗∗P < 0.001; ∗∗P < 0.01).
