Table 2.
Gene Ontology analysis of the S100 genes and their most significantly coexpressed genes in CRC.
| Category | Term | Count | % | p value | FDR |
|---|---|---|---|---|---|
| GOTERM_BP_DIRECT | GO:0006954~inflammatory response | 9 | 17.30769 | 9.11E-06 | 0.012361 |
| GOTERM_BP_DIRECT | GO:0006935~chemotaxis | 6 | 11.53846 | 2.24E-05 | 0.030396 |
| GOTERM_BP_DIRECT | GO:0018149~peptide cross-linking | 4 | 7.692308 | 0.000367 | 0.497246 |
| GOTERM_BP_DIRECT | GO:0070098~chemokine-mediated signaling pathway | 4 | 7.692308 | 0.001028 | 1.385837 |
| GOTERM_BP_DIRECT | GO:0007186~G-protein coupled receptor signaling pathway | 9 | 17.30769 | 0.003201 | 4.257847 |
| GOTERM_BP_DIRECT | GO:0007204~positive regulation of cytosolic calcium ion concentration | 4 | 7.692308 | 0.006236 | 8.138288 |
| GOTERM_CC_DIRECT | GO:0070062~extracellular exosome | 22 | 42.30769 | 5.91E-06 | 0.006523 |
| GOTERM_CC_DIRECT | GO:0001533~cornified envelope | 4 | 7.692308 | 0.000271 | 0.299178 |
| GOTERM_CC_DIRECT | GO:0005886~plasma membrane | 23 | 44.23077 | 0.000633 | 0.696457 |
| GOTERM_CC_DIRECT | GO:0005576~extracellular region | 12 | 23.07692 | 0.003667 | 3.973017 |
| GOTERM_CC_DIRECT | GO:0048471~perinuclear region of cytoplasm | 6 | 11.53846 | 0.027144 | 26.19097 |
| GOTERM_CC_DIRECT | GO:0005887~integral component of plasma membrane | 9 | 17.30769 | 0.037498 | 34.41178 |
| GOTERM_MF_DIRECT | GO:0050786~RAGE receptor binding | 7 | 13.46154 | 1.99E-13 | 2.24E-10 |
| GOTERM_MF_DIRECT | GO:0005509~calcium ion binding | 15 | 28.84615 | 9.3E-09 | 1.05E-05 |
| GOTERM_MF_DIRECT | GO:0044548~S100 protein binding | 4 | 7.692308 | 6.44E-06 | 0.007239 |
| GOTERM_MF_DIRECT | GO:0048306~calcium-dependent protein binding | 4 | 7.692308 | 0.000634 | 0.710203 |
| GOTERM_MF_DIRECT | GO:0019959~interleukin-8 binding | 2 | 3.846154 | 0.008683 | 9.337967 |
| GOTERM_MF_DIRECT | GO:0035662~Toll-like receptor 4 binding | 2 | 3.846154 | 0.011561 | 12.253 |