Table 3.
SOX2-OT is regulated at the transcriptional and posttranscriptional levels.
| Factor | Regulatory effect | Cell model | Reference |
|---|---|---|---|
| NSPc1 | Represses transcription | Glioma cells | Liang et al. [26] |
| MTA3 | Represses transcription | Esophageal squamous cell carcinoma cells | Du et al. [56] |
| SOX2 | Promotes transcription | Esophageal squamous cell carcinoma cells | Wu et al. [15] |
| IRF4 | Promotes transcription | Cholangiocarcinoma cells | Wei et al. [57] |
| YY1 | Represses transcription | Pancreatic ductal adenocarcinoma cells | Zhang et al. [19] |
| AR | Promotes transcription | Embryonic neural stem cells | Tosetti et al. [66] |
| SOX3 | Promotes transcription | Glioblastoma stem cells | Su et al. [65] |
| miR-211 | Downregulates expression by directly binding to SOX2-OT | Embryonal carcinoma stem cells (NT-2) | Shafiee et al. [67] |
| miR-375 | Downregulates expression by directly binding to SOX2-OT | Embryonal carcinoma stem cells (NT-2) | Shafiee et al. [68] |
Note: NSPc1: nervous system polycomb 1; MTA3: metastasis-associated protein 3; IRF4: interferon regulatory factor 4; YY1L Yin Yang-1; ARL androgen receptor; Sox3: SRY-box transcription factor 3.