Table 2.
TCF7L2 rs7903146 genotype association with GDM.
| Model |
Genotype | No GDM | GDM |
Crude analysis |
p trend |
Adjusted analysis∗ |
OR (95% CI) | p trend | AIC |
|---|---|---|---|---|---|---|---|---|---|
| All (n = 857) | OR (95% CI) | AIC | |||||||
| Codominant | C/C | 316 (46.1%) | 94 (54.6%) | 1.00 | 0.038 | 858.8 | 1.00 | 0.09 | 825.3 |
| C/T | 308 (45%) | 59 (34.3%) | 0.64 (0.45–0.92) | 0.69 (0.47–1.01) | |||||
| T/T | 61 (8.9%) | 19 (11.1%) | 1.05 (0.60–1.84) | 1.12 (0.62–2.02) | |||||
| Dominant | C/C | 316 (46.1%) | 94 (54.6%) | 1.00 | 0.046 | 859.4 | 1.00 | 0.13 | 825.7 |
| C/T-T/T | 369 (53.9%) | 78 (45.4%) | 0.71 (0.51–0.99) | 0.76 (0.53–1.08) | |||||
| Recessive | C/C–C/T | 624 (91.1%) | 153 (89%) | 1.00 | 0.4 | 862.6 | 1.00 | 0.33 | 827.2 |
| T/T | 61 (8.9%) | 19 (11.1%) | 1.27 (0.74–2.19) | 1.33 (0.76–2.35) | |||||
| Overdominant | C/C-T/T | 377 (55%) | 113 (65.7%) | 1.00 | 0.011 | 856.9 | 1.00 | 0.03 | 823.4 |
| C/T | 308 (45%) | 59 (34.3%) | 0.64 (0.45–0.91) | 0.68 (0.47–0.97) | |||||
| Log-additive | – | – | – | 0.86 (0.66–1.11) | 0.25 | 862 | 0.90 (0.69–1.19) | 0.47 | 827.6 |
Genotype distributions are shown as n(%) and odds ratio 95% CI (OR). CI, confidence interval; GDM, gestational diabetes mellitus; AIC, Values of Akaike’s Information Criterion; P-trend values were calculated from adjusted or unadjusted logistic regression analysis for codominant, dominant, and recessive models. ∗Adjusted logistic regression by age, ethnicity, parity, family history of DM and pregestational BMI.